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Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium
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 Authours
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Li-Jun Ma, H. Charlotte van der Does, Katherine A. Borkovich, Jeffrey J. Coleman, Marie-Josée Daboussi, Antonio Di Pietro, Marie Dufresne, Michael Freitag, Manfred Grabherr, Bernard Henrissat, Petra M. Houterman, Seogchan Kang, Won-Bo Shim, Charles Woloshuk, Xiaohui Xie, Jin-Rong Xu, John Antoniw, Scott E. Baker, Burton H. Bluhm, Andrew Breakspear, Daren W. Brown, Robert A. E. Butchko, Sinead Chapman, Richard Coulson, Pedro M. Coutinho, Etienne G. J. Danchin, Andrew Diener, Liane R. Gale, Donald M. Gardiner, Stephen Goff, Kim E. Hammond-Kosack, Karen Hilburn, Aurélie Hua-Van, Wilfried Jonkers, Kemal Kazan, Chinnappa D. Kodira, Michael Koehrsen, Lokesh Kumar, Yong-Hwan Lee, Liande Li, John M. Manners, Diego Miranda-Saavedra, Mala Mukherjee, Gyungsoon Park, Jongsun Park, Sook-Young Park, Robert H. Proctor, Aviv Regev, M. Carmen Ruiz-Roldan, Divya Sain, Sharadha Sakthikumar, Sean Sykes, David C. Schwartz, B. Gillian Turgeon, Ilan Wapinski, Olen Yoder, Sarah Young, Qiandong Zeng, Shiguo Zhou, James Galagan, Christina A. Cuomo, H. Corby Kistler & Martijn Rep |
| Title |
Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium |
| Journal |
Nature, 2010 (464) ~ |
Abstract
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Fusarium species are among the most important phytopathogenic and toxigenic fungi. To understand the molecular
underpinnings of pathogenicity in the genus Fusarium, we compared the genomes of three phenotypically diverse species:
Fusarium graminearum, Fusarium verticillioides and Fusarium oxysporum f. sp. lycopersici. Our analysis revealed
lineage-specific (LS) genomic regions in F. oxysporum that include four entire chromosomes and account for more than
one-quarter of the genome. LS regions are rich in transposons and genes with distinct evolutionary profiles but related to
pathogenicity, indicative of horizontal acquisition. Experimentally, we demonstrate the transfer of two LS chromosomes
between strains of F. oxysporum, converting a non-pathogenic strain into a pathogen. Transfer of LS chromosomes between
otherwise genetically isolated strains explains the polyphyletic origin of host specificity and the emergence of new
pathogenic lineages in F. oxysporum. These findings put the evolution of fungal pathogenicity into a new perspective. |
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