| |
|
|
| |
|
|
Research  |
|
|
|
| |
| |
dbHiMo: a web-based epigenomics platform for histone-modifying enzymes
|
|
|
|
|
|
| |
|
 Authours
|
Jaeyoung Choi, Ki-Tae Kim, Aram Huh, Seomun Kwon, Changyoung Hong, Fred O. Asiegbu, Junhyun Jeon, and Yong-Hwan Lee |
| Title |
dbHiMo: a web-based epigenomics platform for histone-modifying enzymes |
| Journal |
DATABASE-OXFORD, 2015 (2015) ~ |
Abstract
|
Over the past two decades, epigenetics has evolved into a key concept for understanding
regulation of gene expression. Among many epigenetic mechanisms, covalent modifications
such as acetylation and methylation of lysine residues on core histones emerged
as a major mechanism in epigenetic regulation. Here, we present the database for histone-modifying
enzymes (dbHiMo; http://hme.riceblast.snu.ac.kr/) aimed at facilitating
functional and comparative analysis of histone-modifying enzymes (HMEs). HMEs were
identified by applying a search pipeline built upon profile hidden Markov model (HMM)
to proteomes. The database incorporates 11 576 HMEs identified from 603 proteomes
including 483 fungal, 32 plants and 51 metazoan species. The dbHiMo provides users
with web-based personalized data browsing and analysis tools, supporting comparative
and evolutionary genomics. With comprehensive data entries and associated web-based
tools, our database will be a valuable resource for future epigenetics/epigenomics
studies. |
Link
|
 |
|
|
| |
|
|
|
|
| |
|
|
|
|
