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Solo or in Concert: SUMOylation in Pathogenic Fungi
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 Authours
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You-Jin Lim and Yong-Hwan Lee |
| Title |
Solo or in Concert: SUMOylation in Pathogenic Fungi |
| Journal |
0, 2025 (41) ~ |
Abstract
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SUMOylation plays a pivotal role in DNA replica
tion and repair, transcriptional stability, and stress
response. Although SUMOylation is a conserved post
translational modification (PTM) in eukaryotes, the
number, type, and function of SUMOylation-associated
components vary among mammals, plants, and fungi.
SUMOylation shares overlapping features with ubiq
uitination, another well-known PTM. However, com
parative studies on the interplay between these two
PTMs are largely limited to yeast among fungal species.
Recently, the role of SUMOylation in pathogenicity
and its potential for crosstalk with ubiquitination have
gained attention in fungal pathogens. In this review, we
summarize recent findings on the distinct components
of SUMOylation across organisms and describe its
critical functions in fungal pathogens. Furthermore, we
propose new research directions for SUMOylation in
fungal pathogens, both independently and in coordina
tion with other PTMs. This review aims to illuminate
the potential for advancing PTM crosstalk research in
fungal systems. |
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